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Matthewzow | Дата: Пятница, 14.03.2014, 14:36 | Сообщение # 16 |
Группа: Гости
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DeborahNare | Дата: Четверг, 20.03.2014, 06:57 | Сообщение # 17 |
Группа: Гости
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fmyykjq | Дата: Понедельник, 21.04.2014, 21:25 | Сообщение # 18 |
Группа: Гости
| Moxidectin (Milbemycin B<> - ) kills parasites, so is acclimated to instead of the mitigation and supervise of heartworm and intestinal worms, and can be found in treatments prescribed in behalf of animals such as dogs, cats, horses, cattle and sheep. Industriousness methods for moxidectin alternate before treatment, and contain vocalized, timely, and injectable solutions. Cydectin Pour On is a swap name for a formulation in place of urgency on stock and red deer. Moxidectin is a semisynthetic derivative of nemadectin <> - which is produced by fermentation next to Streptomyces cyano-griseus. This Streptomyces species was discovered in a defile sample from Australia in the late 1980s at ease during an agronomist working for the American Cyanamid company. Moxidectin treats and controls some of the most unrefined internal and outward parasites on selectively binding to parasites?? glutamate-gated chloride ion channels. These channels are invigorating to the chore of invertebrate tenacity and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite. Studies of moxidectin steer the side effects vary at near rude and may be affected by the result??s formulation, application method and dosage. The products are mainly recommended by a veterinarian to ensure counterbalance avail oneself of and application. Herding dogs may be avermectin-sensitive, but avermectin-sensitive dogs can admit example doses after heartworm prevention. Moxidectin is apparently safe in regard to collie breeds. As a heartworm preventative, moxidectin can be injected in a minute every six months call of the sort rating Proheart6, or every 12 months lower than drunk the brand eminence Proheart SR 12. Moxidectin is the referred to of a effort to assess its suitability, as an alternative to ivermectin, to remedying onchocerciasis in humans.<> - From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd. From http://www.tcsindustry.com - TCS INDUSTRY LTD
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famuyiyaox | Дата: Понедельник, 17.11.2014, 01:04 | Сообщение # 19 |
Группа: Гости
| Moxidectin (Milbemycin B[1 - ) kills parasites, so is hand-me-down because of the arrest and manage of heartworm and intestinal worms, and can be create in treatments prescribed for animals such as dogs, cats, horses, steers and sheep. Industriousness methods towards moxidectin diversify not later than treatment, and register voiced, current, and injectable solutions. Cydectin Spew out On is a barter cite for a formulation in place of from on cows and red deer. Moxidectin is a semisynthetic imitative of nemadectin [2 - which is produced by fermentation at near Streptomyces cyano-griseus. This Streptomyces species was discovered in a excrement sampler from Australia in the tardily 1980s collected by means of an agronomist working as a replacement for the American Cyanamid company. Moxidectin treats and controls some of the most mean internal and apparent parasites by selectively binding to parasites’ glutamate-gated chloride ion channels. These channels are mandatory to the r搇e of invertebrate fortitude and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite. Studies of moxidectin steer the side effects vary by animalistic and may be fake through the yield’s formulation, assiduity method and dosage. The products are mainly recommended around a veterinarian to insure correct speak and application. Herding dogs may be avermectin-sensitive, but avermectin-sensitive dogs can admit paragon doses looking for heartworm prevention. Moxidectin is evidently unharmed as far as something collie breeds. As a heartworm preventative, moxidectin can be injected at one time every six months at the beck the make big cheese Proheart6, or every 12 months answerable to the trade-mark prominence Proheart SR 12. Moxidectin is the referred to of a misery to assess its suitability, as an surrogate to ivermectin, to conduct towards onchocerciasis in humans.[3 - From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
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fmyykjk | Дата: Суббота, 27.12.2014, 17:56 | Сообщение # 20 |
Группа: Гости
| Tamoxifen is an foe of the estrogen receptor in heart conglomeration via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and for this may be characterized as a confused agonist/antagonist. Tamoxifen is the time-honoured endocrine (anti-estrogen) treatment in place of hormone receptor-positive tit cancer in pre-menopausal women, and is also a established in post-menopausal women although aromatase inhibitors are also many a time employed in that setting.[1 - Some breast cancer cells call for estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also tie up to the estrogen receptor but do not activate it. Because of this competitive antipathy, tamoxifen acts like a opener fragmented off in the entangle that prevents any other crucial from being inserted, preventing estrogen from binding to its receptor. For that bosom cancer room development is blocked. Tamoxifen was discovered during pharmaceutical convention Royal Chemical Industries[2 - (age AstraZeneca) and is sold under the business names Nolvadex, Istubal, and Valodex. However, the drug, unvarying in the past its patent coming to an end, was and stationary is extremely referred to via its generic luminary "tamoxifen." Medical uses Core cancer Tamoxifen is currently used with a view the treatment of both original and advanced ER+ (estrogen receptor firm) breast cancer in pre- and post-menopausal women.[3 - Additionally, it is the most general hormone treatment towards male tit cancer.[4 - It is also approved by the FDA pro the prevention of knocker cancer in women at extreme imperil of developing the disease.[5 - It has been accessory approved in the direction of the reduction of contralateral (in the conflicting bosom) cancer. In 2006, the charitable NAME clinical study concluded that raloxifene is equally effective in reducing the incidence of knocker cancer, but after an average 4-year backup there were 36% fewer uterine cancers and 29% fewer blood clots in women engaging raloxifene than in women fascinating tamoxifen, although the discrepancy is not statistically significant.[6 - [7 - [8 - In 2005, the ATAC stab showed that after general 68 months following a 5 year adjuvant treatment, the union that receivedanastrozole (Arimidex) had significantly more wisely results than the tamoxifen platoon in measures like disease on the loose survival, but no overall mortality benefit.[9 - Materials from the trying out intimate that anastrozole should be the preferred medication for postmenopausal women with localized titty cancer that is estrogen receptor (ER) positive.[10 - Another work develop that the risk of recurrence was reduced 40% (with some endanger of bone cleavage) and that ER negative patients also benefited from switching to anastrozole.[11 - [12 - From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
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fmyykjh | Дата: Понедельник, 23.03.2015, 15:03 | Сообщение # 21 |
Группа: Гости
| Milbemycin oxime is vigorous against a frank spectrum of nematodes, although it is less potent against heartworms than ivermectin. Its miticide spectrum includes Sarcoptes and Demodex. The USA FDA green light allow on milbemycin oxime as formulated solely does not indicate insecticidal activity.<> - The quiddity is time combined with other parasiticides to fulfil a broader spectrum of action. Such products categorize: Milbemax (with praziquantel) Lookout Flavor Tabs (with lufenuron) Trifexis (with spinosad) Recently the psychedelic has been acclimated to in maritime reef aquaria to hold sway over parasitic harptacoid copepod (Tegastidae) infestations on caged devastating coral colonies. It is an possessions detailed tank treatment since these parasites because it is not toxic to corals in the dosage required to despatch the parasites. Shrimps, crabs and other crustaceans should be removed till to treatment, as they determination be killed around the treatment. From http://www.tcsindustry.com - TCS INDUSTRY LTD
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famuyiyaox | Дата: Понедельник, 20.04.2015, 17:52 | Сообщение # 22 |
Группа: Гости
| Tacrolimus (also FK-506 or fujimycin, trade names Prograf, Advagraf, Protopic) is an immunosuppressive opiate that is most of all acclimatized after allogeneic medium move to trim down the pursuit of the perseverant's immune system and so lower the gamble of medium rejection. It is also occupied in a topical preparation in the treatment of atopic dermatitis (eczema), strict refractory uveitis after bone marrow transplants, exacerbations of token metamorphose complaint, and the fleece train vitiligo. It is a 23-membered macrolide lactone discovered in 1984 from the fermentation consomm?of a Japanese filth representative that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) production beside T-cells. Dead letter Tacrolimus was discovered in 1984; it was among the opening macrolide immunosuppressants discovered, preceded by the development of rapamycin (sirolimus) on Rapa Nui (Easter Atoll) in 1975.<> - It is produced during a breed of stain bacterium,Streptomyces tsukubaensis.<> - The high regard tacrolimus is derived from 'Tsukuba macrolide immunosuppressant'.<> - Tacrolimus was fundamental approved by the Comestibles and Cure-all Superintendence (FDA) in 1994 someone is concerned end in liver transplantation; this has been extended to embrace kidney, affection, small bowel, pancreas, lung, trachea, overlay, cornea, bone marrow, and limb transplants. Availability The branded version of the medicine is owned by Astellas Pharma, and is sold under the trade names Prograf assumed twice ordinary,Advagraf, a unchanging unfetter formulation allowing a single time finally regular dosing, and Protopic (Eczemus in Pakistan by Brookes Pharma), the current formulation.<> - Advagraf is handy in 0.5, 1, 3 and 5 mg capsules, the not bad is concentrations of 0.1% and 0.03%. A second once-daily formulation of tacrolimus is in Development 3 clinical trials in the U.S. and Europe. This formulation also has a smoother pharmacokinetic list that reduces the peak-to-trough assortment in blood levels compared to twice-daily tacrolimus.<> - Materials from the premier Configuration 3 woe in steady kidney transfer patients showed that this once-daily formulation was non-inferior in efficacy and shelter compared to twice-daily tacrolimus.<> - A next Phase 3 effort in de novo patients is ongoing.<> - Logical positivism of encounter Tacrolimus is chemically known as a macrolide. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to get started calcineurin. Calcineurin then dephosphorylates the transcription constituent NF-AT (nuclear agent of activated T-cells), which moves to the pith of the T-cell and increases the labour of genes coding benefit of IL-2 and tied up cytokines. Tacrolimus prevents the dephosphorylation of NF-AT.<> - In detachment, Tacrolimus reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a up to date complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin wise inhibiting both T-lymphocytesignal transduction and IL-2 transcription.<> - Although this occupation is alike resemble to ciclosporin, studies from shown that the degree of shrewd also brush is reduced about tacrolimus utilization from ciclosporin.<>0 - Although short-term immunosuppression with an eye to acquiescent and shoot survival is develop to be similar between the two drugs, tacrolimus results in a more favorable lipid describe, and this may eat important long-term implications accepted the prognostic affect of also brush on corruption survival.<>1 - From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
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